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It truly is interesting to note that once the DCM-causing mutation K36Q in cTnI was released inside the existence of Ca2+, the simulation showed that Ser 22 and 23 no more interacted closely with cTnC, in accord with our speculation which the Ca2+-cTnC-cTnI N terminus conversation is unique and is also destabilized right by phosphorylation in addit

Novel drug shipping and delivery procedures are another method remaining pursued to beat several of the limiting properties of clofazimine. Clofazimine could be encapsulated in liposomes, allowing for parenteral administration, and that is impossible with the free drug due to its small aqueous solubility (Mehta et al.Structures of Tyr188Leu mutant